Current experimental models have proven their limitation to understand biology of kidney diseases. With an estimated 10% of the population worldwide being affected by kidney diseases, there is a dire need to develop novel in vitro kidney models to support the development of kidney treatment innovations in the future.
Creating a novel microphysiological relevant 3D renal in vitro model by combining two enabling technologies, bioprinting and organ-on-chip. Primary human cells and induced pluripotent stem cells will be used to generate renal progenitor cells and organoids and combined with the aforementioned model envisioning future patient specific therapies.
BIRDIE consortium consists of experienced researchers from European academic institutions and innovative SMEs. The team has highly complementary expertise in translational biology, bioprinting and additive manufacturing, microfluidics, single cell systems, and organ on a chip models.